Antibiotic Could Protect Against Neurodegenerative Diseases During Ageing

Summary: A new study reveals minocycline, a popular antibiotic, can help extend lifespan and improve protein balance in ageing worms. Researchers say the protective mechanism of the medication could be exploited to help prevent neurodegenerative diseases like Alzheimer’s or Parkinson’s in humans. Source: eLife.

An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during ageing, a study in the open-access journal eLife reports.

Protein aggregation causes several progressive age-related brain diseases, including amyotrophic lateral sclerosis, Alzheimer’s, Parkinson’s and prion disease. This study shows that minocycline prevents this build-up even in older animals with age-impaired stress-response pathways.

The number of proteins in a cell is balanced by the rate of protein manufacture and disposal, called proteostasis. As we age, proteostasis becomes impaired. “It would be great if there were a way to enhance proteostasis and extend lifespan and health, by treating older people at the first sign of neurodegenerative symptoms or disease markers such as protein build-up,” says lead author Gregory Solis, a graduate student at Scripps Research, US. “In this study, we investigated whether minocycline can reduce protein aggregation and extend lifespan in animals that already have impaired proteostasis.”

When they used a chemical probe to see how minocycline affects the major protein-regulating molecules in the cell, it revealed that minocycline directly affects the protein-manufacturing machinery of the cell, known as the ribosome. This was true in worms, as well as mouse and human cells. image is in the public domain.

Funding: Funding provided by Lawrence Ellison Foundation, National Institutes of Health, National Science Foundation, Glenn Foundation for Medical Research.

Source: Emily Packer — eLife
Publisher: Organized by
Image Source: image is in the public domain.
Original Research: Open access research for “Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms” by Gregory M Solis, Rozina Kardakaris, Elizabeth R Valentine, Liron Bar-Peled, Alice L Chen, Megan M Blewett, Mark A McCormick, James R Williamson, Brian Kennedy, Benjamin F Cravatt, and Michael Petrascheck in eLife. Published November 27 2018.


Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficient Caenorhabditis elegans by targeting cytoplasmic ribosomes, preferentially attenuating translation of highly translated mRNAs. In contrast to most other longevity paradigms, minocycline inhibits rather than activates all major SSPs and extends lifespan in mutants deficient in the activation of SSPs, lysosomal or autophagic pathways. We propose that minocycline lowers the concentration of newly synthesized aggregation-prone proteins, resulting in a relative increase in protein-folding capacity without the necessity to induce protein-folding pathways. Our study suggests that in old individuals with incapacitated SSPs or autophagic pathways, pharmacological attenuation of cytoplasmic translation is a promising strategy to reduce protein aggregation. Altogether, it provides a geroprotecive mechanism for the many beneficial effects of tetracyclines in models of neurodegenerative disease.