- Cheryl E. G. Leyns,
- Maud Gratuze,
- Sneha Narasimhan,
- Nimansha Jain,
- Lauren J. Koscal,
- Hong Jiang,
- Melissa Manis,
- Marco Colonna,
- Virginia M. Y. Lee,
- Jason D. Ulrich &
- David M. Holtzman
Nature Neuroscience (2019)
Abstract
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer’s disease. Here we show that germline knockout of Trem2 or the TREM2R47H variant reduces microgliosis around amyloid-β plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates. These findings demonstrate a key role for TREM2 and microglia in limiting the development of peri-plaque tau pathologies.