Research

Category: Research

Mouse Model Shows How Parkinson’s Disease Begins in the Gut

Mouse Model Shows How Parkinson’s Disease Begins in the Gut

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease Published: June 26, 2019 DOI: https://doi.org/10.1016/j.neuron.2019.05.035 Interview with Ted Dawson discussing his lab’s demonstration that misfolded α-synuclein which can move from the stomach to the brain and cause physical and cognitive symptoms.: https://www.the-scientist.com/news-opinion/mouse-model-shows-how-parkinsons-disease-begins-in-the-gut-66048

TREM2 function impedes tau seeding in neuritic plaques

TREM2 function impedes tau seeding in neuritic plaques

Cheryl E. G. Leyns, Maud Gratuze, Sneha Narasimhan, Nimansha Jain, Lauren J. Koscal, Hong Jiang, Melissa Manis, Marco Colonna, Virginia M. Y. Lee, Jason D. Ulrich & David M. Holtzman  Nature Neuroscience (2019) Abstract Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer’s […]

Suppression of Tinnitus in Mice Moving to Clinical Trials

Suppression of Tinnitus in Mice Moving to Clinical Trials

“Sometimes scientists can’t discern if something went wrong in an animal model until clinical results show inconsistency. That is why we always exercise caution [about interpreting results with animal models] before we see the confirmation from clinical findings involving people,” Zhang said. Zhang is also a member of the ATA Board of Directors and former chair of the ATA’s Scientific Advisory Committee.

Sham-controlled study of optokinetic stimuli as treatment for Mal de Débarquement Syndrome

Mucci, V., Perkisas, T., Jillings, S.D., Van Rompaey, V., Van Ombergen, A., Fransen, E., Vereeck, L., Wuyts, F.L., Van de Heyning, P.H. and Browne, C.J., 2018. Sham-controlled study of optokinetic stimuli as treatment for Mal de Debarquement Syndrome. Frontiers in Neurology, 9, p.887.